Sodium Hydroxide → HCID 57642391, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5.0 g (0.0249 mole) of ethyl 5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole-4-carboxylate (XVI) in 40 mL of tetrahydrofuran-water-methanol (3:1:1) was added 5 mL of 10 M sodium hydroxide solution. The mixture was heated at 65° C. for 4 hours and then concentrated to a smaller volume under reduced pressure. The pH was adjusted to 1-2 by the addition of hydrochloric acid. The product was collected by filtration, washed with water and dried to yield 4.7 g of 5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole-4-carboxylic acid (XVII) as a tan solid.

Provenance & Evidence