反应详情

5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-7-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (XXIIz) was prepared by reacting 0.003 moles of 5-(2-chlorophenyl)-1,3-dihydro-8-methoxy-7-methyl-2H-1,4-benzodiazepin-2-thione (IIz) with 1,1-diethoxy-N,N-dimethyl-methanamine and then hydrazine in a manner analogous to Example 90. Recrystallization from ethyl acetate-methanol provided 5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-7-methyl-pyrazolo[3,4-b][1,4]benzodiazepine as a light red solid, mp 275-276° C.

1. custom5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-7-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (XXIIz) was prepared
2. customRecrystallization from ethyl acetate-methanol