HCID 91210435, compound → HCID 69030403, compound

Participants

Reaction Steps

Azide 5 (61.0 mg, 0.11 mmol) was hydrogenated with Pd/C (10%, 10 mg) in methanol (5 mL) overnight at room temperature. The mixture was filtered through a bed of CELITE, and the filtrate was then concentrated to give tetraamine 6 (51.5 mg, 100%); 1H-NMR (D2O): δ5.10 (d, 1H, J=3.4 Hz, H-1), 4.06-3.98 (m, 1H, OCHHCH2CH2NH2), 3.96-3.92 (m, 1H, H-4), 3.90˜3.48 (m, 14H, H-2, H-3, H-5, H-6, H-6′, OCH2CH2CH2NH2, and OCH2CH3), 2.89-2.70 (m, 8H, OCH2CH2CH2NH2), 1.90-1.65 (m, 8H, OCH2CH2CH2NH2), 1.18 (t, 3H, J=7.1 Hz, OCH2CH3); ES-MS: 437.48 (M+H)+, 219.16 (M+2H)2+.

Provenance & Evidence