反应详情

A mixture of 5,7-dichloro-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine (3.19 g, 10 mmol), 2,2,2-trifluoroethylamine (3.0 g, 30 mmol), and triethylamine (3.0 g, 30 mmol) in 30 mL of N,N-dimethylformamide is stirred at room temperature under nitrogen atmosphere for 1 h. The reaction mixture is diluted with ethyl acetate. The organic layer is washed with saturated sodium chloride (×3), dried over magnesium sulfate, and concentrated. The residue is filtered through hydrous magnesium silicate. Concentration provides 5-chloro-6-(2,4,6-trifluorophenyl)-N-(2,2,2-trifluoroethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine as a light yellow solid (3.70 g). MS: m/z 381.9 (M+H).

1. washThe organic layer is washed with saturated sodium chloride (×3)
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. filtrationThe residue is filtered through hydrous magnesium silicate
5. concentrationConcentration