HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Amino-5-bromo-3-(hydroxymethyl)pyridine | HCID 10891366 | — |
| Product | 5-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide | HCID 53420052 | — |
Reaction Steps
A solution of 2-amino-5-bromo-3-hydroxymethylpyridine (5.00 g, 24.6 mmole), from Preparation 14 (b), in 48% aqueous HBr (50 mL), was heated at reflux for 12 hrs. The reaction was concentrated and toluene was used to azeotrope the residual H2O. The resulting light brown solid was placed under high vacuum overnight and used directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524843B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-8b901d92f3814e64a5cd5b11b1110d70 |
| Source note | uspto-grants-2009_04 |