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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2112645Generated: October 27, 2026

Sodium Hydroxide → N,1-Dimethyl-5-fluoro-1H-indole-2-carboxamide

https://huagongshe.com/reaction/2112645

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactantethyl 1-methyl-1H-indole-2-carboxylateHCID 143368—
ReactantEthyl 5-fluoro-1-methyl-1H-indole-2-carboxylateHCID 10775338—
ProductN,1-Dimethyl-5-fluoro-1H-indole-2-carboxamideHCID 2259374368%

Reaction Steps

According to the procedure of Preparation 1 (b), except substituting ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylate for the ethyl 1-methyl-1H-indole-2-carboxylate, the title compound (2.1 g, 68%) was prepared as a white solid: MS (ES) m/e 207 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07524843B2
Source datasetuspto-grants-2009_04
ORD IDord-70c76de11b324af084da1cac809f69ff
Source noteuspto-grants-2009_04