Sodium Hydroxide → 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde

HRID 2112689Notes

Reaction equation

HRID 2112689 reaction equation
[OH-:1].[Na+].[CH3:3][N:4]1[C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:7]2[CH:6]=[CH:5]1.[CH3:13]N1C2C(=CC=CC=2)C(C)=C1>>[CH3:3][N:4]1[C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:7]2[C:6]([CH:13]=[O:1])=[CH:5]1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 701301,3-DimethylindoleHCID 583068N-methyl-7-azaindole

Product 1

HCID 104419601-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehydeYield 47%

Procedure

According to the procedure of Preparation 40 (b), except substituting 1-methyl-1H-pyrrolo[2,3-b]pyridine (0.7 g, 5.3 mmole) for the 1,3-dimethylindole, the title compound (0.4 g, 47%) was prepared as a white solid: MS (ES) m/e 161 (M+H)+.

Sources & evidence

ORD record
ord-0cbf56e7ad4940c2ab9e33e66fae10cd
Source dataset
uspto-grants-2009_04
Patent number
US07524843B2

Reaction notes

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