Triphenylphosphine → HCID 86760859, compound

Participants

Reaction Steps

To a mixture of (2S)-oxiran-2-ylmethanol (296 mg, 4.0 mmol), N-(2-hydroxyphenyl)urea (609 mg, 4.0 mmol) and triphenylphosphine (1.05 g, 4.0 mmol) in THF (10 mL) was dropwise added DEAD (697 mg, 4.0 mmol) in THF (3 mL) at room temperature. After addition was completed the reaction mixture was stirred at room temperature over night. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-80% ethyl acetate in petroleum spirit) to give sub-title compound (336 mg).

Provenance & Evidence