Hydrochloric Acid → HCID 23079664, compound

Participants

Reaction Steps

Ethyl 1-(tert-butoxycarbonyl)-4-(3-pyrrolidin-1-ylpropyl)piperidine-4-carboxylate (0.12 g, 0.33 mmol) prepared according to Process Step 2 was mixed with ethanol (1.8 mL) and aqueous sodium hydroxide solution (2.0 mol/L, 1.6 mL, 3.3 mmol), followed by stirring under reflux for fifteen hours. After adjusting the pH to 7.8 by adding diluted hydrochloric acid (6.0 mol/L) added under ice-cooling, the reaction mixture was extracted with n-butanol. The organic layer was dried over anhydrous sodium sulfate. After distilling off the solvent, the residue was dried under reduced pressure and thereby yielded 1-(tert-butoxycarbonyl)-4-(3-pyrrolidin-1-ylpropyl)piperidine-4-carboxylic acid (0.10 g, 91%).

Provenance & Evidence