Trifluoroacetic acid → HCID 68997130, compound

Participants

Reaction Steps

Tert-butyl 4-((2R)-4-ethylmorpholin-2-ylmethyl)piperazinecarboxylate (0.50 g, 1.60 mmol) prepared according to Process Step 1 was dissolved in dichloromethane (5 mL), and the solution was mixed with trifluoroacetic acid (2 mL) added dropwise under ice-cooling. After stirring at room temperature for one hour, the solvent was distilled off under reduced pressure. The resulting yellow oil was dissolved in dioxane (6 mL), and the solution was mixed with triethylamine (3 mL) to thereby yield (2R)-4-ethyl-2-(piperazinylmethyl)morpholine.

Provenance & Evidence