Cyclopropanecarbonyl chloride → HCID 69000631, compound

Participants

Reaction Steps

From 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride prepared according to Reference Example 1 and cyclopropylcarbonyl chloride, 2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine was prepared in the same way as Process Step 1 of Example 1. Further, 2,4-dichloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine was allowed to sequentially react with 2-chloro-4-fluorobenzylamine and N-(2-aminoethyl)(tert-butoxy)carboxamide in the same way as Process Steps 2 and 3 of Example 1, to yield 4-(2-chloro-4-fluorobenzylamino)-6-cyclopropylcarbonyl-2-(2-tert-butoxycarbonylaminoethylamino)-5,6,7,8-tetrahydropyrido [4,3-d]pyrimidine.

Provenance & Evidence