HRID2112767

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCC(C(=O)CN2CCCC2)CC1

HCID23079654

未命名化合物

结构：CC(C)(C)OC(=O)N(Cc1ccc(F)cc1Cl)c1nc(Cl)nc2c1CN(C(=O)C1CC1)CC2

HCID86610787

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N(Cc1ccc(F)cc1Cl)c1nc(N2CCC(C(=O)CN3CCCC3)CC2)nc2c1CN(C(=O)C1CC1)CC2

HCID69002519

未命名化合物

PROCEDURE

实验过程

In the same way as Example 92 mentioned later, 4-(N-tert-butoxycarbonyl-2-chloro-4-fluorobenzylamino)-6-cyclopropylcarbonyl-2-[4-(2-pyrrolidin-1-ylacetyl)piperidino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine was prepared from 4-(N-tert-butoxycarbonyl-2-chloro-4-fluorobenzylamino)-2-chloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine prepared according to Process Step 1 and tert-butyl 4-(2-pyrrolidin-1-ylacetyl)piperidinecarboxylate prepared according to Reference Example 12.

WORKUP

后处理

customprepared
customprepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3cc8527ea824b8f81854226d53a2a88
来源数据集: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07524852B2
来源说明: uspto-grants-2009_04

反应 SMILES

[C:1]([O:5][C:6]([N:8]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=1[Cl:33])[C:9]1[C:10]2[CH2:19][N:18]([C:20]([CH:22]3[CH2:24][CH2:23]3)=[O:21])[CH2:17][CH2:16][C:11]=2[N:12]=[C:13](Cl)[N:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:34]1([CH2:39][C:40]([CH:42]2[CH2:47][CH2:46][N:45](C(OC(C)(C)C)=O)[CH2:44][CH2:43]2)=[O:41])[CH2:38][CH2:37][CH2:36][CH2:35]1>>[C:1]([O:5][C:6]([N:8]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=1[Cl:33])[C:9]1[C:10]2[CH2:19][N:18]([C:20]([CH:22]3[CH2:23][CH2:24]3)=[O:21])[CH2:17][CH2:16][C:11]=2[N:12]=[C:13]([N:45]2[CH2:44][CH2:43][CH:42]([C:40](=[O:41])[CH2:39][N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)[CH2:47][CH2:46]2)[N:14]=1)=[O:7])([CH3:3])([CH3:4])[CH3:2]