Tert-butyl 4-(2-pyrrolidin-1-ylacetyl)piperidinecarboxylate → 4-(N-tert-butoxycarbonyl-2-chloro-4-fluorobenzylamino)-6-cyclopropylcarbonyl-2-[4-(2-pyrrolidin-1-ylacetyl)piperidino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

HRID 2112767Notes

Reaction equation

HRID 2112767 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=1[Cl:33])[C:9]1[C:10]2[CH2:19][N:18]([C:20]([CH:22]3[CH2:24][CH2:23]3)=[O:21])[CH2:17][CH2:16][C:11]=2[N:12]=[C:13](Cl)[N:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:34]1([CH2:39][C:40]([CH:42]2[CH2:47][CH2:46][N:45](C(OC(C)(C)C)=O)[CH2:44][CH2:43]2)=[O:41])[CH2:38][CH2:37][CH2:36][CH2:35]1>>[C:1]([O:5][C:6]([N:8]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=1[Cl:33])[C:9]1[C:10]2[CH2:19][N:18]([C:20]([CH:22]3[CH2:23][CH2:24]3)=[O:21])[CH2:17][CH2:16][C:11]=2[N:12]=[C:13]([N:45]2[CH2:44][CH2:43][CH:42]([C:40](=[O:41])[CH2:39][N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)[CH2:47][CH2:46]2)[N:14]=1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 23079654Tert-butyl 4-(2-pyrrolidin-1-ylacetyl)piperidinecarboxylateHCID 866107874-(N-tert-butoxycarbonyl-2-chloro-4-fluorobenzylamino)-2-chloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Product 1

HCID 690025194-(N-tert-butoxycarbonyl-2-chloro-4-fluorobenzylamino)-6-cyclopropylcarbonyl-2-[4-(2-pyrrolidin-1-ylacetyl)piperidino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Procedure

In the same way as Example 92 mentioned later, 4-(N-tert-butoxycarbonyl-2-chloro-4-fluorobenzylamino)-6-cyclopropylcarbonyl-2-[4-(2-pyrrolidin-1-ylacetyl)piperidino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine was prepared from 4-(N-tert-butoxycarbonyl-2-chloro-4-fluorobenzylamino)-2-chloro-6-cyclopropylcarbonyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine prepared according to Process Step 1 and tert-butyl 4-(2-pyrrolidin-1-ylacetyl)piperidinecarboxylate prepared according to Reference Example 12.

Workup

  1. customprepared
  2. customprepared

Sources & evidence

ORD record
ord-b3cc8527ea824b8f81854226d53a2a88
Source dataset
uspto-grants-2009_04
Patent number
US07524852B2

Reaction notes

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