Benzylamine → 3940-84-9

HRID 2112768Notes

Reaction equation

HRID 2112768 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[C:6](Cl)=[O:7].[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>ClCCl>[CH2:16]([NH:23][C:6](=[O:7])[C:5]1[CH:4]=[C:3]([O:2][CH3:1])[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-

Product 1

HCID 7369623940-84-9

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3,4,5-Trimethoxybenzoyl chloride (5.0 g, 21.7 mmol) was dissolved in dichloromethane (50 ml). The reaction mixture was cooled with an ice-bath and benzylamine (4.74 ml, 43.4 mmol) was added slowly. The solid material was removed by filteration. The filtrate was poured into 30 ml of water. The organic phase was washed several times with water. The crude product was recrystallized from i-propanol.

Workup

  1. temperatureThe reaction mixture was cooled with an ice-bath
  2. customThe solid material was removed by filteration
  3. additionThe filtrate was poured into 30 ml of water
  4. washThe organic phase was washed several times with water
  5. customThe crude product was recrystallized from i-propanol

Sources & evidence

ORD record
ord-40fd6cda864443b59da37abb847797ea
Source dataset
uspto-grants-2009_04
Patent number
US07524853B2

Reaction notes

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