HCID 11718973, compound → HCID 86760858, compound

HRID 2112834Notes

Reaction equation

HRID 2112834 reaction equation
[ClH:1].[F:2][C:3]1[CH:29]=[CH:28][C:6]([CH2:7][NH:8][CH2:9][CH:10]([C:21]2([OH:27])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)=[CH:5][CH:4]=1.FC1C=CC(CNC(=O)C(C2(O)CCCCC2)C2C=CC=C(C(F)(F)F)C=2)=CC=1>>[ClH:1].[ClH:1].[F:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][CH2:9][CH:10]([C:21]2([OH:27])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]2)[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:19])([F:20])[F:18])[CH:12]=2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 11718973HCID 11718973, compoundHCID 68854572HCID 68854572, compound

Product 1

HCID 86760858HCID 86760858, compound

Procedure

In an analogous manner to Example 1, step 2 1-{2-[(4-fluorobenzyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}cyclohexanol hydrochloride was prepared from N-(4-fluorobenzyl)-2-(1-hydroxycyclohexyl)-2-[3-(trifluoromethyl)phenyl]acetamide. MS (ESI) m/z 396 ([M+H]+); HRMS: calcd for C22H25F4NO.HCl, 431.1639; found (ESI), 396.1931.

Sources & evidence

ORD record
ord-0b28fecb2a16440a86b70dbc6a232adf
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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