HCID 68852999, compound → HCID 68855625, compound

HRID 2112850Notes

Reaction equation

HRID 2112850 reaction equation
[ClH:1].Cl.CO[CH:5]1[N:10]([CH2:11][CH2:12][C:13]2([OH:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:9][CH:8](C2C(OC(F)(F)F)=C(C3C=CC=CC=3)C=CC=2)[N:7]([CH3:37])[CH2:6]1.Cl.Cl.[CH3:40][O:41][C:42]1[C:47]([C:48]2[CH:53]=[CH:52][CH:51]=[C:50]([O:54][C:55]([F:58])([F:57])[F:56])[CH:49]=2)=[CH:46][C:45](C(C2(O)CCCCC2)CN2CCNCC2)=[CH:44][CH:43]=1>>[ClH:1].[ClH:1].[CH3:40][O:41][C:42]1[C:47]([C:48]2[CH:53]=[CH:52][CH:51]=[C:50]([O:54][C:55]([F:56])([F:57])[F:58])[CH:49]=2)=[CH:46][C:45]([CH:12]([C:13]2([OH:19])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]2)[CH2:11][N:10]2[CH2:9][CH2:8][N:7]([CH3:37])[CH2:6][CH2:5]2)=[CH:44][CH:43]=1

Participants

3

Reactant 2

HCID 68852999HCID 68852999, compoundHCID 131727429HCID 131727429, compound

Product 1

HCID 68855625HCID 68855625, compound

Procedure

In an analogous manner to Example 24, 1-[1-[6-methoxy-3′-(trifluoromethoxy-1,1′-biphenyl-3-yl]-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol dihydrochloride was prepared from 1-[1-(3′-trifluoromethoxy-6-methoxy-1,1′-biphenyl-3-yl)-2-piperazin-1-ylethyl]cyclohexanol (see Example 251). MS m/z 493; HRMS: calcd for C27H35F3N2O3+H, 493.26780; found (ESI, [M+H]+), 493.2692.

Sources & evidence

ORD record
ord-4a823f995fd94b5f86d305edcc1fbe72
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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