1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol Hydrochloride → HCID 11431038, compound

HRID 2112861Notes

Reaction equation

HRID 2112861 reaction equation
Cl.[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([C:26]2([OH:32])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[CH2:17][N:18]2[CH2:23][CH2:22][CH:21]([O:24][CH3:25])[CH2:20][CH2:19]2)=[CH:12][C:11]=1[Cl:33])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(OC1C=CC(C(C2(O)CCCCC2)C(N2CCC(OC)CC2)=O)=CC=1Cl)C1C=CC=CC=1>>[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([C:26]2([OH:32])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[CH2:17][N:18]2[CH2:19][CH2:20][CH:21]([O:24][CH3:25])[CH2:22][CH2:23]2)=[CH:12][C:11]=1[Cl:33])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 114887861-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol HydrochlorideHCID 688524421-[1-[4-(Benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexanol

Product 1

HCID 11431038HCID 11431038, compound

Procedure

In an analogous manner to Example 1, step 2, 1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol hydrochloride was prepared from 1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexanol. HRMS: calcd for C27H36ClNO3+H+, 458.24565; found (ESI, [M+H]+), 458.2443.

Sources & evidence

ORD record
ord-ea929901c446434c8f006e4a5fcd3fe9
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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