HCID 11750148, compound → HCID 68930823, compound

HRID 2112864Notes

Reaction equation

HRID 2112864 reaction equation
[ClH:1].Cl.[Cl:3][C:4]1[CH:5]=[C:6]([CH:10]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([NH:18][CH3:19])[CH2:14][CH2:13]2)[CH:7]=[CH:8][CH:9]=1>CO>[ClH:3].[ClH:1].[Cl:3][C:4]1[CH:5]=[C:6]([C@H:10]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:11][N:12]2[CH2:13][CH2:14][CH:15]([NH:18][CH3:19])[CH2:16][CH2:17]2)[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 11750148HCID 11750148, compound

Product 1

HCID 68930823HCID 68930823, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Racemic 1-[2-(3-chlorophenyl)-2-cyclohexylethyl]-N-methylpiperidin-4-amine (see Example 232) was dissolved in methanol at a concentration of approximately 50 mg/mL. The resulting solution was injected onto the Preparative High Performance Liquid Chromatography instrument. The baseline resolved enantiomers, using the conditions described below, were collected. The enantiomeric purity of each enantiomer was determined under the same HPLC conditions using a Chiralcel OD-H 5u, 250 mm×4.6 mm ID column at 1.0 mL/min flow rate using an HP 1100 HPLC (Agilent Technologies. Palo Alto, Calif., USA).

Workup

  1. customwere collected

Sources & evidence

ORD record
ord-f70fe52c9b72430dba624e7ee49b87c5
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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