HCID 68851895, compound → HCID 68855259, compound

HRID 2112865Notes

Reaction equation

HRID 2112865 reaction equation
[ClH:1].Cl.[O:3]([C:10]1[CH:11]=[C:12]([CH:16]([C:24]2([OH:30])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:17][N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH:13]=[CH:14][CH:15]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[ClH:1].[ClH:1].[O:3]([C:10]1[CH:11]=[C:12]([C@H:16]([C:24]2([OH:30])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[CH2:17][N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[CH:13]=[CH:14][CH:15]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 68851895HCID 68851895, compound

Product 1

HCID 68855259HCID 68855259, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Racemic 1-[1-(3-phenoxyphenyl)-2-piperazin-1-ylethyl]cyclohexanol (see Example 311) was dissolved in methanol at a concentration of approximately 50 mg/mL. The resulting solution was injected onto the Preparative High Performance Liquid Chromatography instrument. The baseline resolved enantiomers, using the conditions described below, were collected. The enantiomeric purity of each enantiomer was determined under the same HPLC conditions using a Chiralcel OD-H 5u, 250 mm×4.6 mm ID column at 1.0 mL/min flow rate using an HP 1100 HPLC (Agilent Technologies. Palo Alto, Calif., USA).

Workup

  1. customwere collected

Sources & evidence

ORD record
ord-861a8827d79f4e798b9f73d12592c76b
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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