Water → 7-(But-2-YN-1-YL)-8-chloro-3-methyl-3,7-dihydro-1H-purine-2,6-dione

Participants

Reaction Steps

7-(2-Butynyl)-3-methyl-3,7-dihydropurine-2,6-dione (112 g) was dissolved in N,N-dimethylformamide (2200 mL), then N-chlorosuccinimide (75.3 g) was added to this mixture, and the reaction solution was stirred at room temperature for five hours. After completion of the reaction, water (2200 mL) was added to the reaction solution, this was stirred at room temperature for 1.5 hours. A white precipitate was then collected by filtration. The white solid obtained was washed with water and t-butyl methyl ether to give the title compound (117 g).

Provenance & Evidence