HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 3-(tert-butoxycarbonylamino)piperidine-1-carboxylate → 3-(Boc-amino)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 3-(tert-butoxycarbonylamino)piperidine-1-carboxylate | HCID 22258937 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(Boc-amino)piperidine | HCID 4233041 | 100.2% |
Reaction Steps
A mixture of 3-t-butoxycarbonylaminopiperidine-1-carboxylic acid benzyl ester (10 g), 10% palladium on carbon (500 mg), and ethanol (100 mL) was stirred under hydrogen atmosphere at room temperature overnight. The catalyst was removed by filtration, and the filtrate was concentrated to dryness to give the title compound (6.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524847B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-fa31e8080d0c486e97336967231cc6c7 |
| Source note | uspto-grants-2009_04 |