Sodium Bicarbonate → HCID 68835872, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the product of Step 2 (0.419 g, 1.10 mmol) in polyphosphoric acid (10 mL) was heated to 120° C. for 2 h. The viscous mixture was poured onto ice and made basic with saturated aqueous sodium bicarbonate, then extracted with dichloromethane (4×250 mL). Removal of the solvent in vacuo gave a solid which was triturated with methanol then filtered to give 5-(5-methyl-[1,3,4]oxadiazol-2-yl)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (0.185 g, 58%) as a solid. ACPI-MS Found: [M+H]+=294.

Provenance & Evidence