HCID 68835368, compound → HCID 68838675, compound

Participants

Reaction Conditions

Reaction Steps

The product of Step 1, 2-amino-7-bromo-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid N′-isobutyryl-hydrazide (1.0 g, 2.9 mmol) was suspended in neat POCl3 (˜10 mL) and heated to 100° C. for one hour. The mixture was concentrated under reduced pressure and the residue was diluted with water. The pH of the aqueous mixture was made slightly basic by the addition of K2CO3, then extracted with a solution of 9:1 CH2Cl2/MeOH (50 mL). The organics were dried with MgSO4 and concentrated under reduced pressure to give a solid, which was triturated with ether and collected by filtration andried under vacuum to give 7-bromo-5-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-[1,2,4]triazolo[1,5,a]pyridine-2-ylamine, that was used without further purification in Step 3. MS (APCI+): m/z 325.0.

Provenance & Evidence