[2-(Dimethylamino)pyrimidin-5-yl]boronic acid → 2-Amino-7-(2-dimethylamino-pyrimidin-5-yl)-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid hydrazide

Participants

Reaction Steps

2-Amino-7-(2-dimethylamino-pyrimidin-5-yl)-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester, was prepared analogously to Example 28, Step 3, except 2-amino-7-bromo-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester (10.0 g, 35.1 mmol) was used as the starting material (which may be prepared as described in Example 6) and 2-dimethylamino-pyrimidin-5-boronic acid was used in place of 3-pyridyl-boronic acid to give 2-amino-7-(2-dimethylamino-pyrimidin-5-yl)-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid hydrazide. MS (APCI+): m/z 328.3.

Provenance & Evidence