反应详情

Propylmagnesium chloride (1.00 mL) was cooled to 0° C. then charged with 2-(3-ethyl-ureido)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid methoxy-methyl-amide (252 mg, 0.682 mmol) in tetrahydrofuran (4.00 mL). After 24 h the reaction was diluted with tetrahydrofuran and neutralized with NH4Cl. The organic was dried over magnesium sulfate and concentrated leaving a solid. The crude was recrystallized (ethyl acetate) to afford the final product 1-(5-butyryl-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridine-2-yl)-3-ethyl-urea. MS (APCI+): m/z 353.4 (M+H).

1. dry with materialThe organic was dried over magnesium sulfate
2. concentrationconcentrated
3. customleaving a solid
4. customThe crude was recrystallized (ethyl acetate)