1-Bromo-2-butanone → HCID 11696854, compound

Participants

Reaction Steps

A mixture of the product of Step 1 (0.5 g, 1.47 mmol) and 1-bromo-2-butanone (0.22 g, 1.47 mmol) in EtOH (10 mL) was heated to reflux for 3 h. The solvent was removed under reduced pressure; the resulting yellow solid was dissolved in MeOH/CHCl3, and dried onto silica gel. The slurry was then purified by column chromatography on silica gel using 1-4% MeOH/CHCl3 as eluent, to afford 1-ethyl-3-[5-(4-ethyl-thiazol-2-yl)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-urea as a solid. LCMS (APCI+) 394.

Provenance & Evidence