Ethyl isocyanate → HCID 68835955, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of the product of Step 1 (160 mg, 0.52 mmol), ethylisocyanate (205 μL, 2.6 mmol), and dibutyltin diacetate (5 drops) in dry toluene (6 mL) was heated at 125° C. in a microwave reactor for 1 h. After being cooled at room temperature the precipitated solid was filtered and washed with chloroform. The crude product was purified by flash chromatography (gradient 0-2% methanol/chloroform) to give 1-ethyl-3-[5-(2-methyl-thiazol-5-yl)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-urea as a solid. MS m/z 380 (M+H+).

Provenance & Evidence