Ethylamine → HCID 68835013, compound

Participants

Reaction Steps

The product of Step 1 (290 mg, 0.90 mmol) was taken up in DMF (1 mL). TosNCO (0.44 g, 2.3 mmol) was added all at once. The solution became warm and was allowed to cool to room temperature over 1 h. Ethylamine (6 mL of a 2 M solution in THF) was added and the resulting mixture was microwaved at 100° C. for 10 min then at 120° C. for 30 min. The resulting solid was collected by filtration and triturated with CH2Cl2/MeOH to afford 1-[5-(cyclohexyl-methyl-amino)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-ethyl-urea. MS m/z 394 (M+H+).

Provenance & Evidence