Cyclohexylamine → HCID 86235182, compound

HRID 2112973Notes

Reaction equation

HRID 2112973 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[C:9]1[N:14]2[N:15]=[C:16]([NH2:18])[N:17]=[C:13]2[CH:12]=[C:11]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:10]=1>>[CH:1]1([NH:7][C:9]2[N:14]3[N:15]=[C:16]([NH2:18])[N:17]=[C:13]3[CH:12]=[C:11]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)[CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 57643138HCID 57643138, compound

Product 1

HCID 86235182HCID 86235182, compound

Procedure

A mixture of cyclohexylamine (4 mL) and 5-chloro-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine, which may be produced as in Example 1A, (280 mg, 1.14 mmol) was microwaved at 155° C. for 1 h. On cooling, the product was triturated with toluene/cyclohexane, then taken up in CH2Cl2 and washed with aqueous Na2CO3. The organic layer was separated, dried (MgSO4), then concentrated to provide N5-cyclohexyl-7-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine. MS m/z 309 (M+H+).

Workup

  1. custommay be produced as in Example 1A, (280 mg, 1.14 mmol)
  2. customwas microwaved at 155° C. for 1 h
  3. temperatureOn cooling
  4. customthe product was triturated with toluene/cyclohexane
  5. washwashed with aqueous Na2CO3
  6. customThe organic layer was separated
  7. dry with materialdried (MgSO4)
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-b806102430c64ff9a4d9790d5c27a5d9
Source dataset
uspto-grants-2009_04
Patent number
US07524860B2

Reaction notes

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