Ethylamine → HCID 68836197, compound

Participants

Reaction Steps

The product of Step 1 (256 mg, 0.83 mmol) was taken up in DMF (2 mL) and cooled on an ice/water bath. TosNCO (0.18 g, 0.91 mmol) was added all at once. The solution was allowed to stir at room temperature for 1.5 h. Ethylamine (3 mL of a 2 M solution in THF) was added and the resulting solution was microwaved at 120° C. for 10 min. The solution was cooled in the refrigerator overnight and the resulting precipitate was collected by filtration yielding 1-(5-cyclohexylamino-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-3-ethyl-urea. MS m/z 380 (M+H+).

Provenance & Evidence