Ethyl isocyanate → HCID 86618027, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-chloro-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine, which may be produced as in Example 1A (210 mg, 0.86 mmol), ethylisocyanate (600 mg, 8.6 mmol), and dibutyltin diacetate (2 drops) in a mixture of toluene and THF (1:1, 10 mL) was heated at 110° C. with stirring in a sealed tube for 5 h. The homogeneous reaction mixture was cooled to RT. The solvent was removed under reduced pressure and the resulting solid was triturated with chloroform (10 mL) and hexanes (250 mL). The solid was filtered, washed with hexanes, and dried to obtain 1-(5-Chloro-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-3-ethyl-urea LCMS (APCI+) 317.

Provenance & Evidence