Ethylamine → HCID 68835224, compound

Participants

Reaction Steps

The material produced in Step 1 (0.78 g, 2.0 mmol) was split into three batches. Each batch was suspended in DMF (3 mL) and then TsNCO (0.3 ml, 2 mmol) was added. The reaction mixture was stirred at rt overnight. Ethylamine (3 ml of a 2 M solution in THF, 6 mmol) was added and the resulting mixture was irradiated with microwaves at 130° C. for 40 minutes. The three batches were combined, filtered, washed with THF, and dried to afford 4-[2-(3-ethyl-ureido)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-piperazine-1-carboxylic acid tert-butyl ester as a solid. MS (APCI+) 467 (M+1).

Provenance & Evidence