Ethylamine → HCID 68837712, compound

Participants

Reaction Steps

The product of Step 2 (312 mg, 0.60 mol) and ethyl amine (3 mL of a 2 M solution in THF) in DMF (2 mL) was microwaved at 100° C. for 1 h. The homogeneous solution was pre-adsorbed onto SiO2. Silica gel chromatography (5% NEt3/0-5% MeOH/EtOAc) gave an oil which was triturated with EtOAc/hexane to afford the target compound 1-ethyl-3-[5-(1-methyl-piperidin-4-ylamino)-7-pyridin-3-yl[1,2,4]triazolo[1,5-a]pyridin-2-yl]-urea. MS m/z 395 (M+H+).

Provenance & Evidence