Ethylamine → HCID 68838124, compound

Participants

Reaction Steps

TosNCO (0.38 g, 1.93 mmol) was added to a solution of the product of Step 1 (0.26 g, 0.77 mmol) in DMF (2.5 mL). After stirring at room temperature for 24 h, ethylamine (3.5 mL of a 2 M solution in THF, 7 mmol) was added to the homogeneous solution, from which a solid precipitated immediately. The mixture was microwaved at 120° C. for 10 min. After cooling to 5° C. for 1 h, a precipitate was collected by filtration, washed with a small volume of MeOH and dried in vacuo at 60° C. to yield 1-ethyl-3-(5-[methyl-(1-methyl-piperidin-4-yl)-amino]-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-urea. MS m/z 409 (M+H+).

Provenance & Evidence