(3-Acetamidophenyl)boronic acid → 3-(3'-Acetylamino-biphenyl-4-yloxymethyl)-benzoic acid

HRID 2113001Notes

Reaction equation

HRID 2113001 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](I)=[CH:14][CH:13]=2)[CH:5]=1.[C:20]([NH:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1)(=[O:22])[CH3:21]>>[C:20]([NH:23][C:24]1[CH:29]=[C:28]([C:15]2[CH:16]=[CH:17][C:12]([O:11][CH2:10][C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([OH:2])=[O:19])=[CH:13][CH:14]=2)[CH:27]=[CH:26][CH:25]=1)(=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 157274(3-Acetamidophenyl)boronic acidHCID 57643351Methyl 3-((4-iodophenoxy)methyl)benzoate2×

Product 1

HCID 116605083-(3'-Acetylamino-biphenyl-4-yloxymethyl)-benzoic acid

Procedure

3-(3′-Acetylamino-biphenyl-4-yloxymethyl)-benzoic acid was prepared using general procedure 1 from 3-(4-iodo-phenoxymethyl)-benzoic acid methyl ester (of Intermediate 1) and 3-acetamidobenzeneboronic acid (ASDI Incorporated, Newark, Del.). Mass spectrum MH+=362.

Sources & evidence

ORD record
ord-7604b04335f544e2ba38a29900794132
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Reaction notes

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