(6-Fluoropyridin-3-yl)boronic acid → HCID 11508076, compound

HRID 2113008Notes

Reaction equation

HRID 2113008 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](I)=[CH:14][CH:13]=2)[CH:5]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][N:22]=1>>[F:20][C:21]1[N:22]=[CH:23][C:24]([C:15]2[CH:16]=[CH:17][C:12]([O:11][CH2:10][C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([OH:2])=[O:19])=[CH:13][CH:14]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 2783397(6-Fluoropyridin-3-yl)boronic acidHCID 57643351Methyl 3-((4-iodophenoxy)methyl)benzoate2×

Product 1

HCID 11508076HCID 11508076, compound

Procedure

3-[4-(6-Fluoro-pyridin-3-yl)-phenoxymethyl]-benzoic acid was prepared using the procedure described above for the synthesis of Example 4 from 3-(4-iodo phenoxymethyl)-benzoic acid methyl ester (of Intermediate 1) and 2-fluoropyridine-5-boronic acid (ASDI Incorporated, Newark, Del.). Mass spectrum MH+=324.

Sources & evidence

ORD record
ord-a252eec464324e619acb94402e2e3d64
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Reaction notes

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