(3-(1H-pyrazol-1-yl)phenyl)boronic acid → HCID 11595831, compound

HRID 2113016Notes

Reaction equation

HRID 2113016 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](I)=[CH:14][CH:13]=2)[CH:5]=1.[N:20]1([C:25]2[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=2)[CH:24]=[CH:23][CH:22]=[N:21]1>>[N:20]1([C:25]2[CH:26]=[C:27]([C:15]3[CH:16]=[CH:17][C:12]([O:11][CH2:10][C:6]4[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=4)[C:3]([OH:2])=[O:19])=[CH:13][CH:14]=3)[CH:28]=[CH:29][CH:30]=2)[CH:24]=[CH:23][CH:22]=[N:21]1

Participants

3

Reactant 2

HCID 16640530(3-(1H-pyrazol-1-yl)phenyl)boronic acidHCID 57643351Methyl 3-((4-iodophenoxy)methyl)benzoate2×

Product 1

HCID 11595831HCID 11595831, compound

Procedure

3-(3′-Pyrazol-1-yl-biphenyl-4-yloxymethyl)-benzoic acid was prepared using the procedure described above for the synthesis of Example 4 from 3-(4-iodo -phenoxymethyl)-benzoic acid methyl ester (of Intermediate 1) and 3-(1H-pyrazol-1-yl)phenylboronic acid (available from ASDI Inc., Newark, Del.). Mass spectrum MH+=371.

Sources & evidence

ORD record
ord-6eedb5425722422caac320ae64c5ce7e
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Reaction notes

Loading…