Thiophene-3-boronic acid → HCID 11623751, compound

HRID 2113018Notes

Reaction equation

HRID 2113018 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](I)=[CH:14][CH:13]=2)[CH:5]=1.[S:20]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21]1>>[S:20]1[CH:24]=[CH:23][C:22]([C:15]2[CH:16]=[CH:17][C:12]([O:11][CH2:10][C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([OH:2])=[O:19])=[CH:13][CH:14]=2)=[CH:21]1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 57643351Methyl 3-((4-iodophenoxy)methyl)benzoate2×

Product 1

HCID 11623751HCID 11623751, compound

Procedure

3-(4-Thiophen-3-yl-phenoxymethyl)-benzoic acid was prepared using the procedure described above for the preparation of Example 15 from 3-(4-iodo -phenoxymethyl)-benzoic acid methyl ester (of Intermediate 1) and thiophene-3-boronic acid (available from Aldrich Chemical Company, Inc., Milwaukee, Wis.). Mass spectrum MH+=311.

Sources & evidence

ORD record
ord-d9a3845aa64e44ffa8c8b3c5d6cec06a
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Reaction notes

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