HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Chloropyridin-3-yl)boronic acid → 2-[4-(2-Chloro-pyridin-3-yl)-phenoxymethyl]-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Chloropyridin-3-yl)boronic acid | HCID 2762704 | — |
| Reactant | 2-(4-Iodo-phenoxymethyl)-thiazole-4-carboxylic acid ethyl ester | HCID 57643350 | — |
| Product | 2-[4-(2-Chloro-pyridin-3-yl)-phenoxymethyl]-thiazole-4-carboxylic acid | HCID 11674633 | — |
Reaction Steps
2-[4-(2-Chloro-pyridin-3-yl)-phenoxymethyl]-thiazole-4-carboxylic acid was prepared using the procedure described above for the preparation of Example 23 from 2-(4-iodo-phenoxymethyl)-thiazole-4-carboxylic acid ethyl ester (of Intermediate 2) and 2-chloropyridine-3-boronic acid (available from Lancaster Synthesis Ltd., Morecambe, UK). Mass spectrum MH+=347.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524870B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-31d558e26c1845d2a778cd5d53655f91 |
| Source note | uspto-grants-2009_04 |