Isoquinoline-5-boronic acid → HCID 11545045, compound

HRID 2113029Notes

Reaction equation

HRID 2113029 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16](I)=[CH:15][CH:14]=2)[S:9][CH:10]=1)=[O:5])C.[CH:20]1[C:29]2[CH:28]=[CH:27][CH:26]=[C:25](B(O)O)[C:24]=2[CH:23]=[CH:22][N:21]=1>>[CH:20]1[C:29]2[C:24](=[C:25]([C:16]3[CH:15]=[CH:14][C:13]([O:12][CH2:11][C:8]4[S:9][CH:10]=[C:6]([C:4]([OH:3])=[O:5])[N:7]=4)=[CH:18][CH:17]=3)[CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][N:21]=1

Participants

3

Reactant 2

HCID 599474Isoquinoline-5-boronic acidHCID 576433502-(4-Iodo-phenoxymethyl)-thiazole-4-carboxylic acid ethyl ester2×

Product 1

HCID 11545045HCID 11545045, compound

Procedure

2-(4-Isoquinolin-5-yl-phenoxymethyl)-thiazole-4-carboxylic acid was prepared using general procedure 2 from 2-(4-iodo-phenoxymethyl)-thiazole-4-carboxylic acid ethyl ester (of Intermediate 2) and 5-isoquinolineboronic acid (available from Frontier Scientific, Inc., Logan, Utah). Mass spectrum MH+=363.

Sources & evidence

ORD record
ord-4ddc49fa0bb64827a71ea336d56944ef
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Reaction notes

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