2-(Methoxymethyl)benzeneboronic acid → HCID 11537816, compound

HRID 2113039Notes

Reaction equation

HRID 2113039 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17](I)=[CH:16][CH:15]=2)[CH:7]=1)C.[CH3:22][O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1B(O)O>>[CH3:22][O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:17]1[CH:16]=[CH:15][C:14]([O:13][CH2:12][C:8]2[CH:7]=[C:6]([CH2:5][C:4]([OH:3])=[O:21])[CH:11]=[CH:10][CH:9]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 37594082-(Methoxymethyl)benzeneboronic acidHCID 57643348HCID 57643348, compound2×

Product 1

HCID 11537816HCID 11537816, compound

Procedure

[3-(2′-Methoxymethyl-biphenyl-4-yloxymethyl)-phenyl]-acetic acid was prepared using general procedure 4 from [3-(4-iodo-phenoxymethyl)-phenyl]-acetic acid ethyl ester (of intermediate 4) and 2-methoxymethylphenylboronic acid (available from Apollo Scientific Ltd., Stockport, UK). Mass spectrum MH+=363.

Sources & evidence

ORD record
ord-efe61424f8c340cca72bce8e28116af8
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Reaction notes

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