(2-Methoxypyridin-3-yl)boronic acid → HCID 11566461, compound

HRID 2113040Notes

Reaction equation

HRID 2113040 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17](I)=[CH:16][CH:15]=2)[CH:7]=1)C.[CH3:22][O:23][C:24]1[C:29](B(O)O)=[CH:28][CH:27]=[CH:26][N:25]=1>>[CH3:22][O:23][C:24]1[C:29]([C:17]2[CH:16]=[CH:15][C:14]([O:13][CH2:12][C:8]3[CH:7]=[C:6]([CH2:5][C:4]([OH:3])=[O:21])[CH:11]=[CH:10][CH:9]=3)=[CH:19][CH:18]=2)=[CH:28][CH:27]=[CH:26][N:25]=1

Participants

3

Reactant 2

HCID 2762709(2-Methoxypyridin-3-yl)boronic acidHCID 57643348HCID 57643348, compound2×

Product 1

HCID 11566461HCID 11566461, compound

Procedure

{3-[4-(2-Methoxy-pyridin-3-yl)-phenoxymethyl]-phenyl}-acetic acid was prepared using general procedure 4 from [3-(4-iodo-phenoxymethyl)-phenyl]-acetic acid ethyl ester (of intermediate 4) and 2-methoxy-pyridine-3-boronic acid (available from Lan-caster Synthesis Ltd., Lancashire, UK). Mass spectrum MH+=350.

Sources & evidence

ORD record
ord-c8cf789fbdf24dad86f0a7e99456b90a
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Reaction notes

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