Phenylacetaldehyde → HCID 69037927, compound

Participants

Reaction Steps

Sodium triacetoxyborohydride (0.67 g, 3.15 mmol) was added to a stirred solution of tert-butyl 2-[3-amino-6-methyl-2-oxo-1(2H)-pyridinyl]acetate (EXAMPLE 1, STEP 1-3), (0.5 g, 2.10 mmol) and phenyl acetaldehyde (0.18 mL, 2.33 mmol) in 0.24 M acetic acid (0.14 mL) in 1,2-dichloroethane (11 mL). After 16 h the mixture was quenched with water and extracted into ethylacetate. The ethyl acetate layer was washed with sodium carbonate solution and brine, dried (Na2SO4) and evaporated under reduced pressure to a glass. The crude product was purified by flash column chromatography (silicagel, eluant CH2Cl2/MeOH=40/1) to give 0.34 g (1.00 mmol) of a light blue solid compound.

Provenance & Evidence