1,4-Benzodioxan-6-ylamine → HCID 22135528, compound

HRID 2113081Notes

Reaction equation

HRID 2113081 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[C:15](Cl)[N:14]=[N:13][C:12]=2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[O:24]1[C:29]2[CH:30]=[CH:31][C:32]([NH2:34])=[CH:33][C:28]=2[O:27][CH2:26][CH2:25]1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[C:15]([NH:34][C:32]3[CH:31]=[CH:30][C:29]4[O:24][CH2:25][CH2:26][O:27][C:28]=4[CH:33]=3)[N:14]=[N:13][C:12]=2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 891481,4-Benzodioxan-6-ylamineHCID 22135501HCID 22135501, compound

Product 1

HCID 22135528HCID 22135528, compound

Procedure

Analogous to the procedure used to prepare Example 5(b), 4-(4-tert-butyl-phenyl)-6-chloro-3-phenylpyridazine, Example 78(d), (155 mg, 0.5 mmol) and 1,4-benzodioxan-6-amine (80 mg, 0.5 mmol, Aldrich) to give the product as a light yellow crystalline solid. MS (ESI, pos. ion) m/z: 438 (M+1).

Sources & evidence

ORD record
ord-32b5cad0ae6f4da6b01ee2b9ad545f4e
Source dataset
uspto-grants-2009_04
Patent number
US07524874B2

Reaction notes

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