HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoacetate → 5-Bromo-2-methyl-1,3-benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoacetate | HCID 15050 | — |
| Reactant | 2-Amino-4-Bromophenol | HCID 351840 | — |
| Product | 5-Bromo-2-methyl-1,3-benzoxazole | HCID 10104599 | — |
Reaction Steps
A solution of 2-amino-4-bromophenol (1 g, 5.32 mmol) in trimethyl orthoacetate (20 mL) was refluxed for 1.5 hours. The reaction was then cooled and the solvent removed under reduced pressure to give 1.1 g of title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524873B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-b40c06aae95941edb4ad84fc9f93251d |
| Source note | uspto-grants-2009_04 |