4-hydroxy-3-(4-methoxyphenyl)benzyl Alcohol → HCID 22391344, compound

HRID 2113108Notes

Reaction equation

HRID 2113108 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1>CC(C)=O.O=[Mn]=O>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1

Participants

4

Reactant 1

HCID 688406354-hydroxy-3-(4-methoxyphenyl)benzyl Alcohol

Product 1

HCID 22391344HCID 22391344, compoundYield 108.8%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 180AcetoneSolvent

Procedure

A solution of 4-hydroxy-3-(4-methoxyphenyl)benzyl alcohol (5.54 g, 24 mmol) in acetone (250 mL) was treated with MnO2 and the mixture stirred for 3 days. The solid was filtered on diatomaceous earth and the filtrate was concentrated under reduced pressure to afford 5.96 g of title compound as a pale green oil, impure with manganese salts.

Workup

  1. filtrationThe solid was filtered on diatomaceous earth
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2a9f50e3f1694759bfe30566dcc304bc
Source dataset
uspto-grants-2009_04
Patent number
US07524873B2

Reaction notes

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