1-(Quinolin-4-yl)ethan-1-one → 1-(1-Methyl-1H-indol-4-yl)ethanone

HRID 2113128Notes

Reaction equation

HRID 2113128 reaction equation
N1C2C(=CC=CC=2)C(C(=O)C)=CC=1.[CH3:14][N:15]1[C:23]2[C:18](=[C:19]([CH:24]([OH:26])[CH3:25])[CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16]1>[O-2].[Mn+2].ClCCl>[CH3:14][N:15]1[C:23]2[C:18](=[C:19]([C:24](=[O:26])[CH3:25])[CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16]1

Participants

5

Reactant 2

HCID 123401901-(Quinolin-4-yl)ethan-1-oneHCID 223913981-(1-Methyl-1H-indol-4-yl)-ethanol

Product 1

HCID 149872881-(1-Methyl-1H-indol-4-yl)ethanone

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by the same procedure for 1-quinolin-4-yl-ethanone from 1-(1-Methyl-1H-indol-4-yl)-ethanol (3.0 g, 17 mmol), manganese oxide (8.69 g, 100 mmol, Aldrich) and dichloromethane (50 mL). The crude title compound was obtained in form as yellow oil in 98% yield (2.9 g, 16.7 mmol).

Sources & evidence

ORD record
ord-f04b77a2bfc044c4a02d962e6b6de6fc
Source dataset
uspto-grants-2009_04
Patent number
US07524873B2

Reaction notes

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