3-Bromo-5-methoxypyridine → 4-Methoxy-3-(5-methoxypyridin-3-yl)benzaldehyde

HRID 2113134Notes

Reaction equation

HRID 2113134 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.[CH:10]([C:12]1[CH:13]=[CH:14][C:15]([O:21][CH3:22])=[C:16](B(O)O)[CH:17]=1)=[O:11]>>[CH3:22][O:21][C:15]1[CH:16]=[CH:17][C:12]([CH:10]=[O:11])=[CH:13][C:14]=1[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1

Participants

3

Reactant 2

HCID 8171633-Bromo-5-methoxypyridineHCID 27343675-Formyl-2-methoxyphenylboronic acid

Product 1

HCID 223912194-Methoxy-3-(5-methoxypyridin-3-yl)benzaldehydeYield 88.6%

Procedure

The title compound (2.5 g, white solid) was prepared from 3-Bromo-5-methoxypyridine (2.17 g, 0.0116 mol) and (5-formyl-2-methoxyphenyl)boronic acid (2.5 g, 0.014 mol, Matrix Scientific) analogously to Example 69, step 1.

Sources & evidence

ORD record
ord-acf276695a5c4e048463270f9d33769c
Source dataset
uspto-grants-2009_04
Patent number
US07524873B2

Reaction notes

Loading…