1-Phenethylamine, (+)- → ((1R)-1-Phenylethyl){[4-methoxy-3-(5-methoxy(3-pyridyl)) phenyl]methyl}amine

HRID 2113135Notes

Reaction equation

HRID 2113135 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][C:4]=1[C:11]1[CH:12]=[N:13][CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1.[CH3:19][C@@H:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:21]1([C@H:20]([NH:27][CH2:7][C:6]2[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[C:4]([C:11]3[CH:12]=[N:13][CH:14]=[C:15]([O:17][CH3:18])[CH:16]=3)[CH:5]=2)[CH3:19])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 6431891-Phenethylamine, (+)-HCID 223912194-Methoxy-3-(5-methoxypyridin-3-yl)benzaldehyde

Product 1

HCID 60010341((1R)-1-Phenylethyl){[4-methoxy-3-(5-methoxy(3-pyridyl)) phenyl]methyl}amine

Procedure

The title compound (0.8 g, white solid as HCl salt) was prepared from 4-methoxy-3-(5-methoxy(3-pyridyl))benzaldehyde (0.71 g) and (R)-α-methylbenzylamine (0.371 mL) analogously to Example 66, step 3.

Sources & evidence

ORD record
ord-aec8d1c804354ce2bf1ff6aea841e5d2
Source dataset
uspto-grants-2009_04
Patent number
US07524873B2

Reaction notes

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