HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 5-[3-(4-tert-Butyl-2-chloro-phenoxy)-propoxy]-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 4-tert-Butyl-2-chlorophenol | HCID 7380 | — |
| Reactant | Iodide Ion | HCID 30165 | — |
| Reactant | 2-Ethyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester | HCID 11160373 | — |
| Product | 5-[3-(4-tert-Butyl-2-chloro-phenoxy)-propoxy]-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid | HCID 10342801 | — |
Reaction Steps
The title compound was prepared following the general procedures described Example 1, Step 3 and Step 4, employing 2-chloro-4-tert-butylphenol instead of 2-chloro-4-(trifluoroethoxy)phenol for the preparation of the iodide and the intermediate prepared in Example 4, Step 1 as the phenol for coupling with the iodide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524882B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-7667aa3feffa48f589bccecb5ec276c7 |
| Source note | uspto-grants-2009_04 |