Sulfuric Acid → HCID 69025192, compound

Participants

Reaction Steps

Ethyl (2S, 3S)-2-ethyl-3-(2-fluorophenyl)-2,3-dihydroxypropanoate (5.2 g, 20 mmol), 10% palladium on carbon (2.5 g) and concentrated sulfuric acid (0. 53 mL, 10 mmol) were mixed in acetic acid (100 mL). The reaction mixture was hydrogenated at 45 psi for 48 hrs. Sodium acetate (1.7 g, 20 mmol) was added and the reaction mixture was stirred for 10 min before it was filtered through silica gel. Concentration of the filtrate gave essentially pure ethyl (2S)-2-(2-Fluoro-benzyl)-2-hydroxy-butyrate, which was hydrolyzed with KOH (2 N, 25 mL) in methanol (150 mL) to give the title compound.

Provenance & Evidence